Selank and Anxiety: Efficacy, Use Cases, and Benefits
- Published By: Research Chemical
- On: October 10, 2023
- Last Updated on: November 29, 2023
Selank: A Promising Treatment for Anxiety?
The link between Selank and anxiety isn’t the only health benefit of the synthetic peptide, as it can also help improve mood, promote memory retention, and more [1].
Selank is equivalent to Tuftsin, which is naturally occurring and is able to regulate and modify one or more immune functions in the body. It’s also known that Selank has sedative effects similar to benzodiazepines without causing withdrawal, amnesia, or habit-forming issues [1].
Research has shown that Selank can alter the expression of nerve cell genes. This synthetic peptide is able to do this by modulating GABA signaling genes, with the possibility of changing the affinity of the GABA receptor itself [1].
Selank has also been shown to be an effective solution for individuals with mild to severe anxiety symptoms [1].
Anxiety can also cause many other symptoms that can be hard to manage, and Selank has shown efficacy in managing many of them.
Symptoms of fatigue, heart palpitations, headaches, nerve pain, high blood pressure, and more can all be mitigated with the help of the Selank peptide. Anxiety is a common stress response, but it can be debilitating if it isn’t under control [3].
Continuous research on Selank has also displayed that the peptide can help reduce this normal stress response and its effects on learning, memory, and concentration. The synthetic peptide does this by regulating levels of enkephalins in the brain [4].
Not only can it help mitigate these issues, but studies with animals have shown that Selank can potentially restore learning and memory capabilities [4].
Selank is a highly diverse synthetic peptide that can tackle a number of health complications that are common to millions of people all over the world. Current developments with the peptide are vast, but continuous research is needed to understand its full potential.
Studies and clinical trials of Selank’s effects on anxiety
Many aspects of research start with animal studies before scientists move on to human trials. The data recovered from animal trials regarding Selank has been astounding and has given scientists the knowledge to properly administrate the peptide to humans in supervised trials [1].
Currently available information has come from numerous critical studies, one of which focused on the expression of genes involved in neurotransmission [1].
The trial found that Selank has the ability to directly influence these genes in nerve cells. Scientists analyzed changes in intervals of one and three hours after administering Selank or GABA for comparison. Substantial changes were discovered in the expression of 45 genes just one hour after administration [5].
Researchers recorded that 22 genes changed within three hours after the administration of Selank or GABA had passed. Many different areas of research have shown that Selank is a multi-faceted peptide with great potential for a variety of uses [5].
The peptide is capable of mitigating the effects of multiple disorders related to anxiety. Studies have indicated that Selank has pronounced anxiolytic activity. This means the peptide acts as a stable antidepressant, neuropsychotropic, and anti-stress solution [5].
Anxiety-related issues such as aggression and fear reactions also fall under this umbrella, which shows that Selank is positioned to be an excellent option for depression and even those who have PTSD upon approval by the FDA [1].
Side Effects and Efficacy
One of the biggest correlations scientists make with Selank is its similarities to benzodiazepines. Selank has shown the ability to develop effects similar to common tranquilizers at small doses. Benzodiazepines may be common, but they’re known to come with quite a few side effects [2].
Issues with withdrawal, dependence, and amnesia are not found after the administration of the Selank peptide. There isn’t a long list of side effects associated with Selank, but how it’s administered has been a focus among researchers [2].
Individual Animal Administration
The efficacy of Selank was much more pronounced for elevated levels of anxiety with individual administration. The research did not, however, reveal the same findings in circumstances that included unpredictable chronic mild stress conditions [6].
This indicates that the efficacy of Selank is better suited to some circumstances surrounding anxiety than others.
Combined Animal Administration
Scientists also looked at combining Selank and diazepam to see if the peptide’s efficacy changed. This aspect of the study showed that combined administration effectively reduced anxiety in unpredictable chronic mild stress conditions [2].
Anxiety is a complex experience for many people, and this data gives researchers more knowledge on how to properly administer Selank regarding different experiences with anxiety disorders [2].
Additional research is bound to highlight different findings on the efficacy of Selank regarding various types of anxiety. This trial provided some definitive answers that proved Selank isn’t a one-size-fits-all solution, but it can help enhance the benefits of current anxiety treatments [2].
Legality and Where to Buy Selank
Selank may not yet be approved by the FDA, but it is for critical research on this peptide to continue. Scientists are hard at work to determine where Selank can fit in the commercial market.
Research has a way to go before that becomes a widespread possibility. It’s vital that researchers only use the highest quality peptides in their work, and there aren’t many vendors that meet these standards.
Finding a vendor that’s known for high-quality peptides is step number one. They should have a focus on research and providing the knowledge and education scientists need.
The best way to study the links between Selank and anxiety is to start with the most up-to-date information on the peptide itself.
Final Thoughts On Selank
Selank, a synthetic peptide closely related to naturally occurring proteins, has shown promising potential as an anti-anxiety compound in the treatment of generalized anxiety disorder (GAD) [7].
Studies have indicated that Selank can reduce anxiety symptoms and enhance cognitive processes without causing significant negative side effects [8].
Moreover, this peptide has demonstrated the ability to strengthen immune function and reduce inflammatory proteins in blood cells, suggesting potential benefits beyond anxiety treatment [9].
Animal models and clinical trials have provided evidence of Selank’s anxiolytic effects, making it a candidate for further research and development [10].
Selank belongs to a class of molecules called synthetic peptides, which are known for their therapeutic properties [11].
This peptide closely related to brain-derived neurotrophic factor, an important brain growth compound, has been found to modulate serotonin levels in the brain, which are implicated in anxiety regulation [7].
Additionally, Selank treatment has shown potential in reducing cholesterol levels and aiding in brain damage recovery [11].
While more studies are needed to fully understand its molecular stability, dosage, and long-term effects, Selank’s potential as an anti-anxiety peptide and its role in strengthening immune function offer promising avenues for treating anxiety and exploring its broader therapeutic applications [9].
Scientific Research & References:
1. Vyunova, T. V., Andreeva, L., Shevchenko, K., & Myasoedov, N. (2018). Peptide-based anxiolytics: the molecular aspects of heptapeptide Selank biological activity. Protein and Peptide Letters, 25(10), 914-923.
2. Kasian, A., Kolomin, T., Andreeva, L., Bondarenko, E., Myasoedov, N., Slominsky, P., & Shadrina, M. (2017). Peptide Selank enhances the effect of diazepam in reducing anxiety in unpredictable chronic mild stress conditions in rats. Behavioural Neurology, 2017.
3. Monica Shetty, K. P. L. (2017). Study of Anxiolytic Activity in Mice Using Vacha Churnam (Rasayana Preparation-Ayurvedic System of Medicine) (Doctoral dissertation, CL Baid Metha College of Pharmacy, Chennai).
4. Kolik, L. G., Nadorova, A. V., Antipova, T. A., Kruglov, S. V., Kudrin, V. S., & Durnev, A. D. (2019). Selank, peptide analogue of tuftsin, protects against ethanol-induced memory impairment by regulating of BDNF content in the hippocampus and prefrontal cortex in rats. Bulletin of Experimental Biology and Medicine, 167(5), 641-644.
5. Volkova, A., Shadrina, M., Kolomin, T., Andreeva, L., Limborska, S., Myasoedov, N., & Slominsky, P. (2016). Selank administration affects the expression of some genes involved in GABAergic neurotransmission. Frontiers in Pharmacology, 7, 31.
6. Kasian, A., Kolomin, T., Andreeva, L., Bondarenko, E., Myasoedov, N., Slominsky, P., & Shadrina, M. (2017). Peptide Selank enhances the effect of diazepam in reducing anxiety in unpredictable chronic mild stress conditions in rats. Behavioural Neurology, 2017.
7. Nadorova, A. V., Kolik, L. G., Klodt, P. M., Narkevich, V. B., Naplyokova, P. L., Kozlovskaya, M. M., & Kudrin, V. S. (2014). The relationship between the anxiolytic action of selank and the level of serotonin in brain structures during the modeling of alcohol abstinence in rats. Neurochemical journal, 8, 115-120.
8. Azhikova, A. K., Feldman, B. V., Andreeva, L. A., Teply, D. D., Samotrueva, M. A., & Myasoedov, N. F. (2019). Structural transformations of thermal burn wounds in rats under the influence of Semax and Selank neuropeptides. Фармация и фармакология, 7(6 (eng)), 321-331.
9. AL, Y., MA, S., NF, M., & LA, A. (2022). The experimental study of the immunomodulating action of Semax and Selank on the model of „social” stress. Acta Facultatis Pharmaceuticae Universitatis Comenianae, 69(1).
10. Zozulia, A. A., Neznamov, G. G., Siuniakov, T. S., Kost, N. V., Gabaeva, M. V., Serebriakova, E. V., … & Seredenin, S. B. (2008). Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Zhurnal Nevrologii i Psikhiatrii Imeni SS Korsakova, 108(4), 38-48.
11. Mjasoedov, N. F., Andreeva, L. A., Grigorjeva, M. E., Obergan, T. Y., Shubina, T. A., & Lyapina, L. A. (2014, September). The influence of Selank on the parameters of the hemostasis system, lipid profile, and blood sugar level in the course of experimental metabolic syndrome. In Doklady Biological Sciences (Vol. 458, No. 1, p. 267). Springer Nature BV.
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Selank and Anxiety: Efficacy, Use Cases, and Benefits
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