Kisspeptin-10 Side Effects and Developments in Research

kisspeptin 10 side effects

Kisspeptin-10 Research and Side Effects

Diving into potential side effects of Kisspeptin-10 can give researchers a greater understanding of how the peptide can be properly administered to test subjects. Kisspeptin naturally occurs in humans as a hormone-signaling protein [3]. 

The Kisspeptin-10 peptide has garnered interest in research due to its positive effects on hormone secretion related to human reproduction [4].

Researchers are also exploring how the peptide correlates to sex-related behaviors such as motivation and drive. It’s known that the peptide can increase testosterone levels in men, but there is currently little evidence that Kisspeptin-10 has a notable impact on women [4].

The gonadotropin-releasing hormone (GnRH) is affected by Kisspeptin-10, signaling the hormone to help regulate testosterone levels [3].

Many current discoveries regarding the peptide started in animal trials, which generated a great deal of information about what’s now known about its effects on humans [3].

Early research on Kisspeptin-10 showed that it plays a role in the growth of nerves and blood vessels in kidneys [5].

Other studies, including those done on animals, have demonstrated that Kisspeptin can affect areas of the brain that focus on memory consolidation [5]. 

Researchers have discovered a great deal about Kisspeptin-10 over the years. 

The fact that there are multiple use cases for the peptide drives scientists to consider that there’s more yet to be learned about its capabilities – both its potential benefits and side effects. 

Function of Kisspeptin-10

It’s now known that Kisspeptin-10 plays an integral part in human reproductive physiology (RP). This is true from more than one aspect of reproductive health, especially when it comes to issues with infertility. Studies involving rodents have found efficacy in both males and females [6]. 

Researchers are working to discern the benefits of Kisspeptin-10 in reproductive health and how it can be applied to more specific reproductive diseases [6]. 

There are additional potential applications for Kisspeptin-10, as it affects areas of the brain regarding memory consolidation and 3D space orientation [6].

A study that included 29 heterosexual men showed that limbic brain activity was enhanced and increased reward-seeking behavior, overall mood, and drive [6]. 

Kisspeptin-10 also has a primary function in the brain, controlling hormone secretion related to human reproduction. All these findings have scientists looking into the many potential applications for Kisspeptin-10 in humans [6]. 

Kisspeptin-10 Research and Its Applications

Numerous applications are being explored for the Kisspeptin-10 peptide in humans. Some are better understood than others, but there have been a number of new findings over the years that raise the question of what else is possible. 

Fertility, cancer, and sexual dysfunction are just some of the current primary areas of focus for researchers [2,7].


The peptide has been found to play a vital part in the regulation of the hypothalamic-pituitary-gonadal axis. This means Kisspeptin-10 can influence reproduction and fertility

Researchers are using this information to determine whether Kisspeptin-10 can have a positive effect on the symptoms associated with numerous reproductive issues [1].


Other critical use cases for Kisspeptin-10 are also being researched, as it has been discovered that the peptide may help fight against cancer [2].

The Kisspeptin-10 peptide has been shown to have the ability to suppress the spread of melanoma, reduce cell bonding, and prevent cancer cells from moving to other tissues [2]. 

One study found that a variety of metastatic cancer types came with decreased Kisspeptin levels, which shows more prevalence of the peptide regarding cancer prevention [2]

Sexual Dysfunction 

Reproductive disorders and their relationship with reproductive hormones have become a significant focus for scientists.

One area of particular interest is the potential link between Kisspeptin-10 administration and the treatment of hypoactive sexual desire disorder and sexual arousal issues [7].

Studies have explored how Kisspeptin-10 effects the reproductive hormones, particularly on the release of follicle-stimulating hormone (FSH) [8].

Research has shown that Kisspeptin-10 can stimulate FSH release in both men and women, although the response may vary depending on factors such as the menstrual cycle phase [8].

Understanding the role of Kisspeptin-10 in reproductive functioning involves investigating the Kisspeptin receptor and Kisspeptin neurons. 

These elements play a crucial role in regulating the release of reproductive hormones and influencing sexual desire and arousal.

While research has provided substantial supporting information on the efficacy and potential use cases of Kisspeptin-10, there are still unanswered questions in this field. 

Further exploration is needed to fully comprehend the mechanisms underlying the effects of Kisspeptin-10 and its potential applications in addressing reproductive-related issues.

kisspeptin Marble-counter

Advantages of Using Kisspeptin-10 in Research

Developments in research around Kisspeptin-10 have generated a lot of exciting information – and also more questions. 

Scientists are rapidly exploring its efficacy and potential use cases for a wide range of health complications. There’s a gap between men and women regarding the peptide’s use cases, which is part of the reason researchers are interested in running more trials on humans [7,8].

Some findings have led researchers to believe that Kisspeptin-10 could be a better solution to managing or treating specific health concerns than traditional methods, as it has been shown to have fewer side effects than many conventional medicines [7,8].

Finding potential treatment applications is important, but scientists are equally interested in the possible Kisspeptin-10 side effects [7,8].

Side Effects of Using Kisspeptin-10 in Research

Studies on Kisspeptin-10 have shown promising potential in modulating sexual function and reproductive hormone secretion [7,8].

However, several knowledge gaps exist, particularly when comparing the effects of the peptide between men and women.

Currently, the available data primarily focuses on administering Kisspeptin-10 to men, and researchers aim to explore its applications for women’s health and address their unique health issues [7,8].

In terms of safety, serious adverse side effects of Kisspeptin-10 have not been identified, and only a few minor adverse effects have been observed [7,8].

However, there is a possibility that Kisspeptin-10 could potentially impact metabolism and energy homeostasis, based on studies conducted on mice [9].

While animal studies often provide valuable insights applicable to humans, it is important to consider the unique characteristics of human physiology. 

Although additional side effects may emerge with further research, the current evidence suggests that any potential side effects of Kisspeptin-10 are minimal [9].

Studies on Kisspeptin-10

Research on Kisspeptin-10 is ongoing, and scientists are focusing on new studies all the time. Studies show many positives regarding the administration of Kisspeptin-10 for different use cases, but its efficacy needs to be explored further. 

Kisspeptin-10 isn’t meant to be a fix or a cure for various health issues, but it’s being looked at as a potential alternative to many traditional treatments [9]. 

There’s no question that Kisspeptin-10 has many different use cases, but there is still much research to be done. Scientists have garnered information on the peptide for men and women, but there is currently much more information on the topic regarding animals. 

Researchers are also seeking to understand the peptide in greater detail to discern its potential limitations and future applications

Limitations and Future of Kisspeptin-10 Research

A critical consideration of the Kisspeptin-10 peptide is that it is not currently FDA-approved. Scientists must focus solely on research purposes for the peptide, but its future applications look bright, considering what’s already known.

Much of what is currently known about Kisspeptin-10 involves sexual health in men and women. Other aspects, such as emotions, behavior, and kidney health, aren’t yet as well understood [5,7,8].

This isn’t to say there hasn’t been progress in these areas, however, as there are a few exciting notes regarding these categories:

Emotion and Behavior

Kisspeptin-10 has shown the ability to increase limbic brain activity, which in turn helps to increase reward-seeking behavior and improve drive and overall mood. This initially seems less significant from a research perspective, but it gives scientists enough information on the exciting potential uses to warrant further exploration [10].  

Kidney Health 

The peptide and its receptor are found in various locations throughout the kidney. It’s also known that Kisspeptin-10 plays a role in kidney function signaling. Studies that focused on mice concluded that the peptide plays a vital role in the growth of nerves and blood vessels in the kidney [5].

There’s much research around Kisspeptin-10 that can still be performed and refined, but to this point, the peptide has been shown to have many potential health benefits for humans [5].

It’s a matter of time before additional information on the peptide comes to light, but this will only be possible if researchers use the highest quality peptides for every aspect of their research [5].

Future Areas Of Study

In kisspeptin research, promising but uncharted areas of research must be studied. These include:

  1. LH Secretion Mechanisms: We’re still uncovering how kisspeptin precisely influences LH secretion.

  2. Sexual Brain Processes: The brain regions and circuits involved in kisspeptin’s role in sexual processing are yet to be fully mapped.

  3. Long-Term Effects of Kisspeptin Treatment: We need a clearer picture of how extended kisspeptin therapy impacts reproductive health and hormones.

  4. Interactions with Neurotransmitter Systems: Kisspeptin’s interaction with neurotransmitter systems like GnRH neurons requires deeper investigation.

  5. Beyond RP: Exploring kisspeptin’s effects on processes like blood pressure regulation, skin aging, and immune function remains a relatively unexplored frontier.

These areas promise exciting discoveries as we unravel the mysteries of kisspeptin’s influence on human physiology. Stay tuned for insights into these uncharted realms of research.

The Source for the Best Peptides

Kisspeptin-10 is making significant headway in research, and the number of potential use cases continues to rise with new discoveries. Sexual dysfunction, cancer, and fertility are primary focuses in many studies, and scientists continue to explore new avenues for the peptide.

It’s critical for researchers to use the best possible peptides to yield the most accurate results. Research Chemical is the resource for lab-tested, certified, quality research products.

Visit the Research Chemical’s website for more information on the highest-quality peptides and SARMs, as well as for industry news, product updates, and more. Reach out today.

Scientific Research & References:​

1. Hameed, Saira, Channa N. Jayasena, and Waljit S. Dhillo. “Kisspeptin and fertility.” Journal of Endocrinology 208.2 (2011): 97.

2. Ciaramella, V., Della Corte, C. M., Ciardiello, F., & Morgillo, F. (2018). Kisspeptin and cancer: molecular interaction, biological functions, and future perspectivesFrontiers in endocrinology9, 115.

3. Anjum, S., Krishna, A., Sridaran, R., & Tsutsui, K. (2012). Localization of gonadotropin‐releasing hormone (GnRH), gonadotropin‐inhibitory hormone (GnIH), kisspeptin and GnRH receptor and their possible roles in testicular activities from birth to senescence in mice. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology317(10), 630-644.

4. Ratnasabapathy, R., & S Dhillo, W. (2013). The effects of kisspeptin in human reproductive function–therapeutic implications. Current Drug Targets14(3), 365-371.

5. Ten, S. C., Gu, S. Y., Niu, Y. F., An, X. F., Yan, M., & He, M. (2010). Central administration of kisspeptin-10 inhibits water and sodium excretion of anesthetized male rats and the involvement of arginine vasopressin. Endocrine research35(3), 128-136.

6. Lyon, J. (2017). Fertility2017. Fertility2017, 37.

7. Ghaderpour, S., Ghiasi, R., Heydari, H., & Keyhanmanesh, R. (2021). The relation between obesity, kisspeptin, leptin, and male fertility. Hormone Molecular Biology and Clinical Investigation43(2), 235-247.

8. Jayasena, C. N., Nijher, G. M., Comninos, A. N., Abbara, A., Januszewki, A., Vaal, M. L., … & Dhillo, W. S. (2011). The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. The Journal of Clinical Endocrinology & Metabolism96(12), E1963-E1972.

9. Chang, B., Song, C., Gao, H., Ma, T., Li, T., Ma, Q., … & Cao, S. (2021). Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance. Reproductive Biology and Endocrinology19, 1-13.

10. Mills, E. G., O’Byrne, K. T., & Comninos, A. N. (2019, March). Kisspeptin as a behavioral hormone. In Seminars in Reproductive Medicine (Vol. 37, No. 02, pp. 056-063). Thieme Medical Publishers.


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Kisspeptin-10 Side Effects and Developments in Research