A synthetic peptide hormone, CJC-1295 + DAC or more commonly known as CJC 1295, is a GHRH analog that can induce the secretion of growth hormones in controlled laboratory settings.
What makes this compound stand out from other peptides is its ability to bind with albumin post-administration. This results in an extended half-life along with a longer duration for action compared to traditional GHRH peptides – making it highly effective over prolonged periods.
This powerful peptide was developed using advanced biochemical techniques by Dr John Kopchick JJ at Ohio University’s Edison Biotechnology Institute.
Since then, numerous clinical research involving CJC-1295 has demonstrated how effectively this product works under specific conditions in research settings.
The properties that CJC-1295 possess make it particularly beneficial for detailed studies on the effects of growth hormones on various biological processes. For example, aging-related studies where declining levels of natural human GH are closely linked can be tested. Other areas include metabolism regulation and tissue repair process investigations.
Crafted as a synthetic analog to growth hormone-releasing factor (GRF), CJC-1295 DAC is designed for controlled stimulation of human growth hormone (HGH) release.
This peptide is composed of four amino acids arranged in a specific sequence enhancing its biological activity and stability.
‘DAC’ stands for Drug Affinity Complex within the context of CJC 1295 DAC. The inclusion extends the half-life by allowing it to stay active longer than naturally occurring GRF.
This extended duration stems from CJC-1295 DAC’s ability to bind with serum albumin post-administration and slowly release over time – making it attractive for long-term studies requiring sustained HGH simulation.
A key property underpinning why CJC-1295 works effectively in lab studies thus far lies in its resistance against enzymatic degradation or breakdown inside test subjects, attributed largely due to its unique structure including the DAC component.
In clinical research involving CJC-1295, an observed increase in plasma growth hormone levels was noted up until about week two after injection, showcasing how effective this compound can be when investigating hormonal regulation processes within animal studies.
An interesting feature about CJC-1295 is its ability to preserve normal physiologic release, making it an exciting subject matter within endocrinology-related experiments where maintaining hormonal balance remains critical.
In another intriguing investigation, it was discovered that adding DAC can potentially influence longevity-related biological processes, which makes it crucial for future aging studies.
CJC-1295 is a growth hormone secretagogue that stimulates the release of growth hormone from the anterior pituitary. Growth Hormone promotes increased growth hormone levels, muscle growth, and bone density.
CJC-1295 is generally well-tolerated in healthy subjects and has shown a favorable safety profile in clinical trials with minimal adverse reactions.
DAC, which stands for Drug Affinity Complex, is an added chemical compound in CJC-1295 DAC, allowing for prolonged stimulation of growth hormone release. This modification extends the peptide’s half-life and enables continuous stimulation of growth hormone secretion.
Ipamorelin and CJC-1295 are both growth hormone secretagogues that stimulate the release of growth hormone from the pituitary gland. They work synergistically to increase growth hormone levels. Additionally, their combination has shown potential in promoting longevity and overall well-being by positively influencing growth hormone secretion and insulin-like growth factor levels in recent laboratory research.
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1. Timms, M., Ganio, K., Forbes, G., Bailey, S., & Steel, R. (2019). An immuno polymerase chain reaction screen for the detection of CJC‐1295 and other growth‐hormone‐releasing hormone analogs in equine plasma. Drug testing and analysis, 11(6), 804-812
2. Teichman, S. L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J. P., & Frohman, L. A. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. The Journal of Clinical Endocrinology & Metabolism, 91(3), 799-805.
3. Sackmann-Sala, L., Ding, J., Frohman, L. A., & Kopchick, J. J. (2009). Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Hormone & IGF Research, 19(6), 471-477.
4. Ionescu, M., & Frohman, L. A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. The Journal of Clinical Endocrinology & Metabolism, 91(12), 4792-4797.
5. Pinyot, A., Nikolovski, Z., Bosch, J., Such-Sanmartín, G., Kageyama, S., Segura, J., & Gutiérrez-Gallego, R. (2012). Growth hormone secretagogues: out of competition. Analytical and bioanalytical chemistry, 402, 1101-1108.
6. Campbell, R. M., Bongers, J., & Felix, A. M. (1995). Rational design, synthesis, and biological evaluation of novel growth hormone releasing factor analogues. Biopolymers: Original Research on Biomolecules, 37(2), 67-88.
7. Campbell, R. M., Stricker, P., Miller, R., Bongers, J., Liu, W., Lambros, T., … & Heimer, E. P. (1994). Enhanced stability and potency of novel growth hormone-releasing factor (GRF) analogues derived from rodent and human GRF sequences. Peptides, 15(3), 489-495.
8. Teichman SL, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. The Journal of Clinical Endocrinology & Metabolism. 2006;91(3):799-805. doi: 10.1210/jc.2005-1536.
9. Ionescu, M., & Frohman, L. A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. The Journal of Clinical Endocrinology & Metabolism, 91(12), 4792-4797.
10. Ma, X., Lin, L., Yue, J., Pradhan, G., Qin, G., Minze, L. J., … & Sun, Y. (2013). Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance. Nutrition & diabetes, 3(12), e99-e99.
Please note that the above references provide evidence for the potential benefits of CJC 1295 DAC Peptide as stated in the product description. For more in-depth information, kindly refer to these scholarly works.
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