selank peptides

Selank: Exploring the Nootropic Benefits of this Synthetic Compound

 Selank, a synthetic peptide, is not like other amino acids as it is a 7-amino-acid peptide that is the synthetic equivalent of the naturally occurring peptide called tuftsin. Selank has garnered significant attention in scientific research, particularly in the field of nootropics, although it is NOT a nootropic, but a research chemical.

As researchers delve into its potential, they are discovering its efficacy in nootropic effects such as regulating immune functions, reducing anxiety, improving mood, and enhancing memory retention, as demonstrated in rat studies.

The peptide falls into the category of research chemicals, which encompass various compounds aimed at enhancing cognitive processes and brain metabolism.

It is also being studied for its effects on anxiety-related symptoms, mood, and is currently being researched for its ability to promote memory retention.

Nootropics are research substances that aim to improve a wide variety of cognitive functions. They are divided into four unique groups, including classical nootropic compounds and chemicals increasing brain metabolism that can aid in memory storage process/processes.

Combining the benefits of Selank with nootropics offers a vast array of potential health advantages. Although substantial research is still needed, both Selank and traditional anxiety treatments have already exhibited success in multiple applications.

In terms of its effects, the Selank peptide is quite similar to those of benzodiazepines. It modulates GABA signaling genes and can also alter the expression of nerve cell genes.

By administering Selank, symptoms associated with anxiety, such as fatigue, heart palpitations, headaches, nerve pain, and depression, can be alleviated as demonstrated in animal models.

Selank is gaining more attention with each passing year as developments in research continue to discover new benefits and use cases for the peptide. Studies have indicated that controlling the side effects of anxiety is one of the many uses of Selank, but a very important one.

The peptide has been shown to help reduce the typical stress response and its adverse effects on learning, concentration, and memory. Getting a firm grasp on the capabilities of Selank requires breaking down the science behind how the peptide works


The Science of Selank

Selank’s mechanism of action is quite diverse. Research has shown that Selank has numerous benefits, such as reducing pain and fatigue by slowing the breakdown of enkephalins.

It can also benefit the immune system and cause modulation of inflammation by affecting specific genes that can assist immune function.

Scientists have explored a number of use cases for Selank, some of which are outlined below.

Institute of Molecular Genetics

The Institute of Molecular Genetics has played a significant role in unraveling the potential of the peptide Selank. Ongoing studies have revealed that the peptide Selank acts as an important brain growth compound.

It modulates cognitive functions and mitigates the negative cognitive impact of generalized anxiety disorders. It achieves this by restoring cognition, concentration, and memory that may be affected by the stress response.

Mechanism of Action

The peptide’s mechanism of action involves its close relation to brain-derived neurotrophic factor (BDNF) and its ability to regulate serotonin levels and metabolism.

Selank is a synthetic peptide derived from naturally occurring proteins, and it exhibits minimal side effects. Its anxiolytic activity and potential to curb anxiety make it a promising therapeutic option.

Selank is often administered via nasal spray, and its effects are being explored in clinical trials. Beyond anxiety and asthenic disorders, Selank has shown potential in areas such as reducing cholesterol levels and modulating immune system responses.

Through its interaction with blood cells and its effect on inflammatory proteins, Selank offers a multifaceted approach to promoting overall well-being. More clinical trials are needed to confirm this information.

Selank and Cognitive Enhancement

Scientists have seen that Selank can have unique restorative effects on learning and memory as seen in mice studie. This is true for those who have suffered brain damage to varying degrees. 

Selank has the ability to cause inhibition of the catecholamine system in the brain, which can contribute to the restorative effects of the peptide.

Selank has been shown to work against the effects of cognitive decline, and it has the ability to regulate enkephalin levels in the brain.

Selank and Mood Enhancement

The Selank peptide benefits work against many different health conditions within the body. Our mood can be affected for many reasons, but Selank’s properties focus on factors such as stress reduction, relief from depression, and the effects of social anxiety.

The peptide has been shown to help regulate the prevalence at the source of these health complications.

Selank and Energy

Energy in the body involves many factors. Those who suffer from fatigue and lack of sleep tend to struggle with their energy levels. Selank has the ability to combat this from multiple angles.

One approach is that Selank can help preserve enkephalins in the brain. These are considered natural painkillers, helping to ward off pain and fatigue.

Administration of Selank has displayed that it can improve sleep, support wakefulness throughout the day, and reduce common symptoms of fatigue.

The effects of Selank on issues like fatigue vary depending on individual physiology, but the data shows a substantial level of efficacy with proper administration. Clinical studies are a crucial part of what we currently know about the peptide, many of which stem from animal research.

We know through research that there are many potential benefits to Selank, but researchers have also been exploring its possible side effects as well.

Selank Side Effects and Precautions

The peptide may have many similarities to benzodiazepines, but research shows that Selank doesn’t come with issues with tolerance. Selank’s side effects are quite minimal, and those that are less common are still manageable.

More common side effects related to Selank include:

    • Headaches

    • Mild fatigue

    • Dizziness

    • Anxiety

    • Nausea

In rare circumstances, Selank has been shown to cause:

    • Irritability

    • Joint pain

    • Insomnia

    • Muscle cramps

These are relatively minor side effects, however, and current research shows they are unlikely to occur. Side effects related to the nervous system were not mentioned in the studies compiled.

Researchers are also exploring how Selank works in combination with other compounds. Data shows that other chemicals can impact Selank’s effectiveness. 

The amount of data available on Selank is substantial, but researchers are hard at work to uncover even more information on efficacy, side effects, and uses of the peptide. 

It may be some time before Selank becomes widely commercially available, but there’s no question that the benefits speak for themselves. 

Top-notch research requires working with the highest-quality peptides and tools available. There are multiple vendors for Selank on the market, but not all offer the same quality. 

Researchers should only work with those who take pride in the quality of the products they offer.

Work with the Best in the Industry

Research Chemical sells top-of-the-line peptides in liquid and powder form for your research needs – look no further than Research Chemical for the highest quality peptides. 

Visit the Research Chemical’s research blog for information about new products, updates in the industry, side effects, recent scientific literature, and product comparisons.  Contact us today.

Scientific Research & References:

1. Volkova, A., Shadrina, M., Kolomin, T., Andreeva, L., Limborska, S., Myasoedov, N., & Slominsky, P. (2016). Selank administration affects the expression of some genes involved in GABAergic neurotransmission. Frontiers in Pharmacology7, 31.

2. L G Kolik, A V Nadorova, T A Antipova, S V Kruglov, V S Kudrin, A D Durnev (Oct. 17th, 2019). Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. National Library of Medicine. PMID: 31625062

3. Matěj Malík and Pavel Tlustoš (Aug. 17th, 2022). Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs. National Library of Medicine. PMCID: PMC9415189

4. Kasian, A., Kolomin, T., Andreeva, L., Bondarenko, E., Myasoedov, N., Slominsky, P., & Shadrina, M. (2017). Peptide Selank enhances the effect of diazepam in reducing anxiety in unpredictable chronic mild stress conditions in rats. Behavioural Neurology2017.

5. Kolomin T, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul Pept. 2011 Oct 10;170(1-3):18-23. doi: 10.1016/j.regpep.2011.05.001. Epub 2011 May 24. PMID: 21609736.

6. Nicolaus, B. J. (1982). Chemistry and pharmacology of nootropics. Drug Development Research, 2(5), 463-474.

7. Zozulya AA, Kost NV, Yu Sokolov O, Gabaeva MV, Grivennikov IA, Andreeva LN, Zolotarev YA, Ivanov SV, Andryushchenko AV, Myasoedov NF, Smulevich AB. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull Exp Biol Med. 2001 Apr;131(4):315-7. doi: 10.1023/a:1017979514274. PMID: 11550013.

8. Semenova, T. P., Kozlovskaya, M. M., Zuikov, A. V., Kozlovskii, I. I., Zakharova, N. M., & Andreeva, L. A. (2008). Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from antenatal hypoxia. Neuroscience and Behavioral Physiology38, 203-207.

9. Semenova TP, Kozlovskaya MM, Zakharova NM, Kozlovskii II, Zuikov AV. Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny. Bull Exp Biol Med. 2007 Nov;144(5):689-91. doi: 10.1007/s10517-007-0406-2. PMID: 18683497.

10. Medvedev, V. E., Tereshchenko, O. N., Kost, N. V., Ter-Israelyan, A. Y., Gushanskaya, E. V., Chobanu, I. K., … & Myasoedov, N. F. (2015). Optimization of the treatment of anxiety disorders with selank. Zhurnal Nevrologii i Psikhiatrii Imeni SS Korsakova115(6), 33-40.


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Selank Peptides: Nootropic Benefits and Potential Side Effects Being Studied